Disposition Kinetics of lincomycin following intravenous administration in hypothyroid goats
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Published:2019-01-31
Issue:of
Volume:
Page:
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ISSN:0976-0555
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Container-title:Indian Journal of Animal Research
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language:
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Short-container-title:IJAR
Author:
Sharma Meemansha,Dumka Vinod Kumar,Singla Saloni,Kaur Rajdeep,Singh Raushan Kumar
Abstract
Hypothyroidism is a common disorder of small ruminants and is expected to alter the pharmacokinetics of drugs. Hypothyroidism was induced by feeding thiourea at the dose rate 50 mg.kg-1 daily for 28 days to goats. Disposition of lincomycin, after intravenous administration at dose rate 10 mg/kg, was investigated in hypothyroid goats to determine the potential dosage regimen against susceptible microorganisms. Blood samples were collected from 1 min to 24 h of drug administration. The drug was detected in plasma up to 8 h and lincomycin was rapidly distributed from blood to the tissue, as evidenced by the high value of the distribution coefficient (mean ± SEM) 12.3±1.09 h-1. The large Vd (1.78±0.18 L/kg) indicated vast tissue distribution of lincomycin in goats. The elimination half life, AUC and total body clearance were 3.99± 0.25 h, 33.2±1.71 ìg.h/mL and 0.31±0.02 L/h/kg, respectively. Based on results, lincomycin in hypothyroid goats is suggested to be repeated at 12 h interval for organisms sensitive to lincomycin having MIC up to 0.1 µg.ml-1.
Publisher
Agricultural Research Communication Center
Subject
General Veterinary,Animal Science and Zoology