Immune Targets Druggability of Mycoplasma synoviae in Chicken

Abstract

Background: Mycoplasma synoviale (Ms), the smallest and simplest bacteria, is categorized as an atypical organism that lacks cell wall. It is a worldwide economically important pathogen of poultry, causing respiratory affections, synovitis, abnormalities in eggshell and drop in production in chickens and turkeys. The present study was conducted to evaluate the druggability targets of Mycoplasma synoviae on cytokines and antioxidant changes in commercial broilers. Methods: Two hundred and eighty, day-old, unsexed broiler chicks of strain Vencobb were randomly allotted to 7 treatment groups with each treatment having 4 replicates and each replicate consisting of 10 birds. Cytokines and antioxidant parameters were determined. Result: Cytokines, TBARS, SOD, catalase and GSH levels showed a significant (P less than 0.05) difference between various treatment groups. Therefore, it is necessary to havea regular survey on poultry pathogenic mycoplasmas and to monitor antimicrobial susceptibility patterns in order to ensure that effective chemotherapy is being used to treat mycoplasmal infections.