ONE-DIMENSIONAL BIOLOGICAL MODEL OF SYNOVIAL JOINTS REGENERATIVE REHABILITATION IN OSTEOARTHRITIS

Author:

Popov Valentin L.,Poliakov Aleksandr,Pakhaliuk Vladimir

Abstract

This work is devoted to the study of a one-dimensional phenomenological model of a focal defect regenerative rehabilitation in the articular cartilage. The model is based on six differential equations in partial derivatives of the “Diffusion-Reaction” type, which was previously used by a number of authors to study cellular processes in various tissues under cell therapy conditions. To take into account the influence of moderate mechanical stimulation of immature tissue, an indirect approach was used, as a result of which some model parameters that directly affect cell proliferation and differentiation were varied considering experimental data. The results of  the model study  show that moderate stimulation of immature tissue in the early stages of repair the focal articular cartilage defect under conditions of cell therapy leads to an intensification of regenerative processes in the tissue and promotes more rapid formation of the extracellular matrix.

Publisher

University of Nis

Subject

Industrial and Manufacturing Engineering,Polymers and Plastics,Mechanical Engineering,Mechanics of Materials,Civil and Structural Engineering

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3