Anti-inflammatory effect of caffeic acid phenethyl ester supplementation on TNF-α and NF-κB expressions throughout experimental tooth movement in vivo
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Published:2022-11-01
Issue:6
Volume:10
Page:1037-1045
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ISSN:0719-4250
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Container-title:Journal of Pharmacy & Pharmacognosy Research
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language:
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Short-container-title:J Pharm Pharmacogn Res
Author:
Salikha Kirana,
Narmada Ida Bagus,
Alida Alida,
Nugraha Alexander PateraORCID,
Sari Annisa Fitria,
Riawan Wibi,
Noor Tengku Natasha Eleena Binti Tengku Ahmad
Abstract
Context: Orthodontic tooth movement (OTM) changes the periodontal tissue and increases the incidence of root resorption (OIRR). Caffeic acid phenethyl ester (CAPE), an antioxidant and anti-inflammatory chemical generated from honey propolis, might be useful in controlling inflammation during OTM and so reducing the risk of OIRR. Aims: To evaluate if CAPE supplementation has an anti-inflammatory impact on tumor necrosis factor-α (TNF-α) and nuclear transcription factor κB (NF-κB) during experimental OTM in male Wistar rats (Rattus novergicus). Methods: Forty-eight healthy male Wistar rats were divided into positive control group (OTM 10 g/mm2 force application) and experimental group (OTM application and CAPE administration). Each groups were observed for 3, 7, 14 days. A nickel-titanium closed coil spring that was 8.0 mm long, thick was inserted between the upper left first molar and upper central incisor in order to move the molar mesially. A 20 mg/kg body weight dose of CAPE was taken orally. Using immunohistochemistry, the expression of TNF-α and NF-κB was examined on the compression side of the OTM. Both the Tukey's honest significant difference test and the one-way analysis of variance test were applied (p<0.05). Results: TNF-α and NF-κB expression in the compression side differed considerably across groups (p<0.05). Daily administration of CAPE significantly downregulates TNF-α and NF-κB expression on the compression side. Conclusions: Administration of CAPE throughout OTM can successfully reduce the number of TNF-α and NF-κB expressions in the compression side in vivo.
Publisher
Garval Editorial Ltda.
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology,Pharmacy,Complementary and alternative medicine
Cited by
1 articles.
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