Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI 3K pathway inhibitors in PTEN ‐null triple negative breast cancer-Reference-Cited by-同舟云学术

Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI 3K pathway inhibitors in PTEN ‐null triple negative breast cancer

Published:2020-07-16 Issue:8 Volume:12 Page:
ISSN:1757-4676
Container-title:EMBO Molecular Medicine
language:en
Short-container-title:EMBO Mol Med

Author:

Zecchin Davide¹,Moore Christopher¹,Michailidis Fanourios¹,Horswell Stuart²,Rana Sareena¹³,Howell Michael⁴,Downward Julian¹³^ORCID

Affiliation:

1. Oncogene Biology Francis Crick Institute London UK

2. Computational Biology Francis Crick Institute London UK

3. Lung Cancer Group Institute of Cancer Research London UK

4. High Throughput Screening Laboratories Francis Crick Institute London UK

Funder

Cancer Research UK

Medical Research Council

Wellcome Trust

FP7 Ideas: European Research Council

Publisher

EMBO

Subject

Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.202011987

Reference61 articles.

1. Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion

2. Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors

3. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

4. Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells

5. PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells

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