Chlorambucil targets BRCA 1/2‐deficient tumours and counteracts PARP inhibitor resistance

Author:

Tacconi Eliana MC1,Badie Sophie1,De Gregoriis Giuliana1,Reisländer Timo1ORCID,Lai Xianning1,Porru Manuela2,Folio Cecilia1,Moore John3,Kopp Arnaud4,Baguña Torres Júlia5,Sneddon Deborah5,Green Marcus3,Dedic Simon1,Lee Jonathan W1,Batra Ankita Sati6,Rueda Oscar M6,Bruna Alejandra6,Leonetti Carlo2,Caldas Carlos6,Cornelissen Bart5,Brino Laurent4,Ryan Anderson3,Biroccio Annamaria2ORCID,Tarsounas Madalena1ORCID

Affiliation:

1. Genome Stability and Tumorigenesis Group Department of Oncology The CR‐UK/MRC Oxford Institute for Radiation Oncology University of Oxford Oxford UK

2. Area of Translational Research IRCCS Regina Elena National Cancer Institute Rome Italy

3. Lung Cancer Translational Science Research Group Department of Oncology The CR‐UK/MRC Oxford Institute for Radiation Oncology University of Oxford Oxford UK

4. Institut de Génétique et de Biologie Cellulaire et Moléculaire (IGBMC) Inserm U1258, CNRS (UMR 7104) Université de Strasbourg Illkirch France

5. Radiopharmaceuticals and Molecular Imaging Group Department of Oncology The CR‐UK/MRC Oxford Institute for Radiation Oncology University of Oxford Oxford UK

6. Department of Oncology Cancer Research UK Cambridge Institute University of Cambridge Cambridge UK

Funder

Cancer Research UK

Medical Research Council

University of Oxford

H2020 Marie Skłodowska-Curie Actions

Ministry of Health

Associazione Italiana per la Ricerca sul Cancro

Publisher

EMBO

Subject

Molecular Medicine

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