Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis

Author:

Zhu Yuyu12ORCID,Wu Zhigui1,Yan Wei3ORCID,Shao Fenli1,Ke Bowen4,Jiang Xian3,Gao Jian1,Guo Wenjie1,Lai Yuping5,Ma Hongyue2,Chen Dijun1ORCID,Xu Qiang1,Sun Yang16ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology Department of Biotechnology and Pharmaceutical Sciences School of Life Sciences Nanjing University Nanjing China

2. College of Pharmacy Nanjing University of Chinese Medicine Nanjing China

3. Department of Dermatology and Venereology West China Hospital Sichuan University Chengdu China

4. Laboratory of Anesthesia and Critical Care Medicine Department of Anesthesiology Translational Neuroscience Center, West China Hospital and State Key Laboratory of Biotherapy Sichuan University Chengdu Sichuan China

5. Shanghai Key Laboratory of Regulatory Biology School of Life Sciences East China Normal University Shanghai China

6. Chemistry and Biomedicine Innovation Center (ChemBIC) Nanjing University Nanjing China

Funder

National Natural Science Foundation of China

Publisher

EMBO

Subject

Molecular Medicine

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