IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia

Author:

Liu Xiaoxiao1ORCID,Sato Naru2ORCID,Yabushita Tomohiro2,Li Jingmei1,Jia Yuhan1,Tamura Moe1,Asada Shuhei23ORCID,Fujino Takeshi2,Fukushima Tsuyoshi2,Yonezawa Taishi1,Tanaka Yosuke2,Fukuyama Tomofusa2ORCID,Tsuchiya Akiho2,Shikata Shiori2,Iwamura Hiroyuki4ORCID,Kinouchi Chieko5,Komatsu Kensuke5ORCID,Yamasaki Satoshi6,Shibata Tatsuhiro6,Sasaki Atsuo T7,Schibler Janet8,Wunderlich Mark8,O'Brien Eric9,Mizukawa Benjamin8,Mulloy James C8,Sugiura Yuki10,Takizawa Hitoshi11ORCID,Shibata Takuma12,Miyake Kensuke12,Kitamura Toshio2,Goyama Susumu1ORCID

Affiliation:

1. Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan

2. Division of Cellular Therapy, The Institute of Medical Science The University of Tokyo Tokyo Japan

3. The Institute of Laboratory Animals, Tokyo Women's Medical University Tokyo Japan

4. FUJIFILM Corporation: Pharmaceutical Products Division Tokyo Japan

5. FUJIFILM Corporation: Bio Science & Engineering Laboratories Kanagawa Japan

6. Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science The University of Tokyo Tokyo Japan

7. Division of Hematology and Oncology, Department of Internal Medicine University of Cincinnati Cincinnati OH USA

8. Division of Experimental Hematology and Cancer Biology Cincinnati Children's Hospital Medical Center Cincinnati OH USA

9. Division of Oncology, Department of Pediatrics, University of Cincinnati Cincinnati OH USA

10. Department of Biochemistry Keio University School of Medicine Tokyo Japan

11. Laboratory of Stem Cell Stress, International Research Center for Medical Sciences Kumamoto University Kumamoto Japan

12. Division of Innate Immunity, Department of Microbiology and Immunology The Institute of Medical Science, The University of Tokyo Tokyo Japan

Funder

National Institute of Neurological Disorders and Stroke

Kobayashi Foundation for Cancer Research

Princess Takamatsu Cancer Research Fund

St. Baldrick's Foundation

Publisher

EMBO

Subject

Molecular Medicine

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