An aberrant sugar modification of BACE 1 blocks its lysosomal targeting in A lzheimer's disease-Reference-Cited by-同舟云学术

An aberrant sugar modification of BACE 1 blocks its lysosomal targeting in A lzheimer's disease

Published:2015-01-15 Issue:2 Volume:7 Page:175-189
ISSN:1757-4676
Container-title:EMBO Molecular Medicine
language:en
Short-container-title:EMBO Mol Med

Author:

Kizuka Yasuhiko¹,Kitazume Shinobu¹,Fujinawa Reiko¹,Saito Takashi²,Iwata Nobuhisa²³,Saido Takaomi C²,Nakano Miyako⁴,Yamaguchi Yoshiki⁵,Hashimoto Yasuhiro⁶,Staufenbiel Matthias⁷,Hatsuta Hiroyuki⁸,Murayama Shigeo⁸,Manya Hiroshi⁹,Endo Tamao⁹,Taniguchi Naoyuki¹

Affiliation:

1. Disease Glycomics Team RIKEN‐Max Planck Joint Research Center Global Research Cluster RIKEN Wako Japan

2. Laboratory for Proteolytic Neuroscience RIKEN Brain Science Institute Wako Japan

3. Department of Genome‐based Drug Discovery Unit of Molecular Medicinal Sciences Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan

4. Graduate School of Advanced Sciences of Matter Hiroshima University Higashihiroshima Hiroshima Japan

5. Structural Glycobiology Team RIKEN‐Max Planck Joint Research Center Global Research Cluster RIKEN Wako Japan

6. Department of Biochemistry Fukushima Medical University School of Medicine Fukushima Japan

7. Novartis Institutes for Biomedical Research Basel Switzerland

8. Department of Neuropathology Research Team for Mechanism of Aging Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology Itabashi‐ku Tokyo Japan

9. Molecular Glycobiology Research Team for Mechanism of Aging Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology Itabashi‐ku Tokyo Japan

Publisher

EMBO

Subject

Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.201404438

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5. The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate

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