IGSF 10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty

Author:

Howard Sasha R1,Guasti Leonardo1,Ruiz‐Babot Gerard1,Mancini Alessandra1,David Alessia2,Storr Helen L1,Metherell Lousie A1,Sternberg Michael JE2,Cabrera Claudia P34,Warren Helen R45,Barnes Michael R34,Quinton Richard6,Roux Nicolas789,Young Jacques10111213,Guiochon‐Mantel Anne101112,Wehkalampi Karoliina14,André Valentina15,Gothilf Yoav16,Cariboni Anna1517,Dunkel Leo1ORCID

Affiliation:

1. Centre for Endocrinology William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK

2. Centre for Integrative Systems Biology and Bioinformatics Department of Life Sciences Imperial College London London UK

3. Centre for Translational Bioinformatics William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK

4. NIHR Barts Cardiovascular Biomedical Research Unit Queen Mary University of London London UK

5. Department of Clinical Pharmacology William Harvey Research Institute Barts and The London School of Medicine Queen Mary University of London London UK

6. Institute of Genetic Medicine University of Newcastle‐upon‐Tyne Newcastle‐upon‐Tyne UK

7. Unité Mixte de Recherche 1141 Institut National de la Santé et de la Recherche Médicale Paris France

8. Université Paris Diderot Sorbonne Paris Cité Hôpital Robert Debré Paris France

9. Laboratoire de Biochimie Assistance Publique‐Hôpitaux de Paris Hôpital Robert Debré Paris France

10. Univ Paris‐Sud Le Kremlin Bicêtre France

11. INSERM UMR‐1185 Le Kremlin Bicêtre France

12. Assistance Publique‐Hôpitaux de Paris Bicêtre Hospital Le Kremlin‐Bicêtre France

13. Department of Reproductive Endocrinology Bicêtre Hospital Le Kremlin‐Bicêtre France

14. Children's Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland

15. Department of Pharmacological and Biomolecular Sciences University of Milan Milan Italy

16. Department of Neurobiology The George S. Wise Faculty of Life Sciences and Sagol School of Neuroscience Tel‐Aviv University Tel Aviv Israel

17. Institute of Ophthalmology University College London (UCL) London UK

Funder

Wellcome Trust

Rosetrees Trust

Biotechnology and Biological Sciences Research Council

Suomen Akatemia

Medical Research Council

Fondazione Telethon

Publisher

EMBO

Subject

Molecular Medicine

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