Genetic and hypoxic alterations of the micro RNA ‐210‐ ISCU 1/2 axis promote iron–sulfur deficiency and pulmonary hypertension

Author:

White Kevin1,Lu Yu1,Annis Sofia1,Hale Andrew E1,Chau B Nelson2,Dahlman James E3456,Hemann Craig7,Opotowsky Alexander R18,Vargas Sara O9,Rosas Ivan10,Perrella Mark A1011,Osorio Juan C10,Haley Kathleen J10,Graham Brian B12,Kumar Rahul12,Saggar Rajan13,Saggar Rajeev14,Wallace W Dean13,Ross David J13,Khan Omar F56,Bader Andrew34,Gochuico Bernadette R15,Matar Majed16,Polach Kevin16,Johannessen Nicolai M17,Prosser Haydn M18,Anderson Daniel G3456,Langer Robert3456,Zweier Jay L7,Bindoff Laurence A1920,Systrom David10,Waxman Aaron B10,Jin Richard C1,Chan Stephen Y1

Affiliation:

1. Divisions of Cardiovascular Medicine and Network Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA

2. Regulus Therapeutics San Diego CA USA

3. Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA USA

4. Harvard‐MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA USA

5. Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA USA

6. David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA USA

7. The Davis Heart and Lung Research Institute Division of Cardiovascular Medicine Department of Internal Medicine Wexner Medical Center The Ohio State University Columbus OH USA

8. Department of Cardiology Boston Children's Hospital Harvard Medical School Boston MA USA

9. Department of Pathology Boston Children's Hospital Harvard Medical School Boston MA USA

10. Division of Pulmonary/Critical Care Medicine Department of Medicine Harvard Medical School Boston MA USA

11. Department of Pediatric Newborn Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA

12. Program in Translational Lung Research University of Colorado Denver, Aurora CO USA

13. Departments of Medicine and Pathology David Geffen School of Medicine University of California, Los Angeles Los Angeles CA USA

14. Department of Cardiothoracic Surgery University of Arizona College of Medicine Phoenix AZ USA

15. Medical Genetics Branch National Human Genome Research Institute National Institutes of Health Bethesda MD USA

16. Celsion‐EGEN, Inc. Huntsville AL USA

17. Department of Cardiology University of Bergen Bergen Norway

18. The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton, Cambridge UK

19. Department of Clinical Medicine University of Bergen Bergen Norway

20. Department of Neurology Haukeland University Hospital Bergen Norway

Publisher

EMBO

Subject

Molecular Medicine

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