Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

Author:

Karlstetter Marcus12,Kopatz Jens3,Aslanidis Alexander1,Shahraz Anahita3,Caramoy Albert1,Linnartz‐Gerlach Bettina3,Lin Yuchen4,Lückoff Anika1,Fauser Sascha1,Düker Katharina3,Claude Janine3,Wang Yiner3,Ackermann Johannes3,Schmidt Tobias5,Hornung Veit56,Skerka Christine4,Langmann Thomas1ORCID,Neumann Harald3ORCID

Affiliation:

1. Laboratory for Experimental Immunology of the Eye Department of Ophthalmology University of Cologne Cologne Germany

2. Therapeutic Research Group Ophthalmology Bayer Pharma AG Wuppertal Germany

3. Institute of Reconstructive Neurobiology University Hospital Bonn University of Bonn Bonn Germany

4. Leibniz Institute for Natural Product Research and Infection Biology Jena Germany

5. Institute of Molecular Medicine University Hospital Bonn University of Bonn Bonn Germany

6. Gene Center and Department of Biochemistry Ludwig‐Maximilians‐Universität München Munich Germany

Funder

Deutsche Forschungsgemeinschaft

Gemeinnützige Hertie-Stiftung

Bundesministerium für Bildung und Forschung

Publisher

EMBO

Subject

Molecular Medicine

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