Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies

Author:

Freedman Joshua D1,Hagel Joachim1,Scott Eleanor M1,Psallidas Ioannis2,Gupta Avinash3,Spiers Laura3,Miller Paul3,Kanellakis Nikolaos2ORCID,Ashfield Rebecca4,Fisher Kerry D1,Duffy Margaret R1,Seymour Leonard W1ORCID

Affiliation:

1. Department of Oncology University of Oxford Oxford UK

2. Oxford Centre for Respiratory Medicine Oxford University Hospitals NHS Trust Oxford UK

3. Churchill Hospital Oxford University Hospital NHS Trust Oxford UK

4. Jenner Institute University of Oxford Oxford UK

Funder

Cancer Research UK

Medical Research Council

Kay Kendall Leukaemia Fund

Publisher

EMBO

Subject

Molecular Medicine

Reference37 articles.

1. Relationship between CD107a expression and cytotoxic activity

2. Bispecific T-Cell Engaging Antibodies for Cancer Therapy: Figure 1.

3. Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody

4. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g;Boyum A;Scand J Clin Lab Invest Suppl,1968

5. MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

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