A high‐affinity, bivalent PDZ domain inhibitor complexes PICK 1 to alleviate neuropathic pain

Author:

Christensen Nikolaj R12,De Luca Marta1,Lever Michael B1,Richner Mette3,Hansen Astrid B1,Noes‐Holt Gith1,Jensen Kathrine L1,Rathje Mette1,Jensen Dennis Bo4,Erlendsson Simon5,Bartling Christian RO2,Ammendrup‐Johnsen Ina1,Pedersen Sofie E1,Schönauer Michèle2,Nissen Klaus B2,Midtgaard Søren R6ORCID,Teilum Kaare5,Arleth Lise6,Sørensen Andreas T1,Bach Anders2,Strømgaard Kristian2,Meehan Claire F4,Vægter Christian B3,Gether Ulrik1,Madsen Kenneth L1ORCID

Affiliation:

1. Molecular Neuropharmacology and Genetics Laboratory Department of Neuroscience Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

2. Center for Biopharmaceuticals Department of Drug Design and Pharmacology Faculty of Health and Medicine University of Copenhagen Copenhagen Denmark

3. Danish Research Institute of Translational Neuroscience (DANDRITE) Nordic‐EMBL Partnership for Molecular Medicine Department of Biomedicine Aarhus University Aarhus C Denmark

4. Department of Neuroscience Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

5. Structural biology and NMR Laboratory Department of Biology University of Copenhagen Copenhagen Denmark

6. Structural Biophysics Niels Bohr Institute University of Copenhagen Copenhagen Denmark

Funder

Sundhed og Sygdom, Det Frie Forskningsråd

Teknologi og Produktion, Det Frie Forskningsråd

Lundbeckfonden

Novo Nordisk Fonden

Publisher

EMBO

Subject

Molecular Medicine

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