Protective antigenic sites identified in respiratory syncytial virus fusion protein reveals importance of p27 domain
Author:
Affiliation:
1. Division of Viral Products Center for Biologics Evaluation and Research (CBER) FDA, Silver Spring MD USA
Funder
U.S. Food and Drug Administration
Publisher
EMBO
Subject
Molecular Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.202013847
Reference16 articles.
1. Cotton rats previously immunized with a chimeric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immunization with vaccinia—RSV recombinants or RSV
2. Priorities for developing respiratory syncytial virus vaccines in different target populations
3. Development of bioluminescence imaging of respiratory syncytial virus (RSV) in virus-infected live mice and its use for evaluation of therapeutics and vaccines
4. Antigenic Fingerprinting following Primary RSV Infection in Young Children Identifies Novel Antigenic Sites and Reveals Unlinked Evolution of Human Antibody Repertoires to Fusion and Attachment Glycoproteins
5. Development of a simple, rapid, sensitive, high-throughput luciferase reporter based microneutralization test for measurement of virus neutralizing antibodies following Respiratory Syncytial Virus vaccination and infection
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