Affiliation:
1. Department of Infectious Disease Imperial College London London UK
2. MRC‐University of Glasgow Centre for Virus Research Glasgow UK
3. Department of Biochemistry University of Cambridge Cambridge UK
4. MRC Laboratory of Molecular Biology Cambridge UK
Abstract
AbstractViruses are vulnerable as they transmit between hosts, and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive and biodegradable small molecule propylene glycol (PG) has robust virucidal activity. Propylene glycol rapidly inactivates a broad range of viruses including influenza A, SARS‐CoV‐2 and rotavirus and reduces disease burden in mice when administered intranasally at concentrations commonly found in nasal sprays. Most critically, vaporised PG efficiently abolishes influenza A virus and SARS‐CoV‐2 infectivity within airborne droplets, potently preventing infection at levels well below those tolerated by mammals. We present PG vapour as a first‐in‐class non‐toxic airborne virucide that can prevent transmission of existing and emergent viral pathogens, with clear and immediate implications for public health.
Funder
Royal Society of Chemistry
UK Research and Innovation
Wellcome Trust
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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