Propylene glycol inactivates respiratory viruses and prevents airborne transmission

Author:

Styles Christine T1ORCID,Zhou Jie1,Flight Katie E1,Brown Jonathan C1ORCID,Lewis Charlotte2,Wang Xinyu3,Vanden Oever Michael1ORCID,Peacock Thomas P1ORCID,Wang Ziyin1ORCID,Millns Rosie1,O'Neill John S4ORCID,Borodavka Alexander3ORCID,Grove Joe2ORCID,Barclay Wendy S1,Tregoning John S1,Edgar Rachel S1ORCID

Affiliation:

1. Department of Infectious Disease Imperial College London London UK

2. MRC‐University of Glasgow Centre for Virus Research Glasgow UK

3. Department of Biochemistry University of Cambridge Cambridge UK

4. MRC Laboratory of Molecular Biology Cambridge UK

Abstract

AbstractViruses are vulnerable as they transmit between hosts, and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive and biodegradable small molecule propylene glycol (PG) has robust virucidal activity. Propylene glycol rapidly inactivates a broad range of viruses including influenza A, SARS‐CoV‐2 and rotavirus and reduces disease burden in mice when administered intranasally at concentrations commonly found in nasal sprays. Most critically, vaporised PG efficiently abolishes influenza A virus and SARS‐CoV‐2 infectivity within airborne droplets, potently preventing infection at levels well below those tolerated by mammals. We present PG vapour as a first‐in‐class non‐toxic airborne virucide that can prevent transmission of existing and emergent viral pathogens, with clear and immediate implications for public health.

Funder

Royal Society of Chemistry

UK Research and Innovation

Wellcome Trust

Publisher

Springer Science and Business Media LLC

Subject

Molecular Medicine

Reference67 articles.

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