The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology-Reference-Cited by-同舟云学术

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology

Published:2017-12-05 Issue:1 Volume:10 Page:32-47
ISSN:1757-4676
Container-title:EMBO Molecular Medicine
language:en
Short-container-title:EMBO Mol Med

Author:

Martinez Hernandez Ana¹²,Urbanke Hendrik¹,Gillman Alan L³^ORCID,Lee Joon³,Ryazanov Sergey⁴⁵,Agbemenyah Hope Y⁶,Benito Eva¹,Jain Gaurav¹,Kaurani Lalit⁵,Grigorian Gayane⁷,Leonov Andrei⁴⁵,Rezaei‐Ghaleh Nasrollah⁴⁸,Wilken Petra⁵⁶⁹,Arce Fernando Teran³,Wagner Jens¹⁰,Fuhrman Martin¹⁰,Caruana Mario¹¹,Camilleri Angelique¹¹,Vassallo Neville¹¹,Zweckstetter Markus⁴⁵⁸¹²,Benz Roland¹³,Giese Armin¹⁴,Schneider Anja⁵⁶⁹,Korte Martin⁷¹⁵^ORCID,Lal Ratnesh³^ORCID,Griesinger Christian⁴⁵^ORCID,Eichele Gregor²^ORCID,Fischer Andre¹⁶^ORCID

Affiliation:

1. Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases German Center for Neurodegenerative Diseases (DZNE) Göttingen Germany

2. Department for Genes and Behavior Max Planck Institute for Biophysical Chemistry Göttingen Germany

3. Department of Bioengineering, Materials Science and Engineering Department of Mechanical and Aerospace Engineering and Institute of Engineering in Medicine University of California San Diego La Jolla CA USA

4. Department of NMR Based Structural Biology Max Planck Institute for Biophysical Chemistry Göttingen Germany

5. DFG Research Center Nanoscale Microscopy and Molecular Physiology of the Brain Göttingen Germany

6. Department of Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany

7. Department of Cellular Neurobiology Technical University Braunschweig Braunschweig Germany

8. Department of Translational Structural Biology of Dementia German Center for Neurodegenerative Diseases (DZNE) Göttingen Germany

9. Group for Translational Research in Neurodegenerative Diseases German Center for Neurodegenerative Diseases (DZNE) Göttingen Göttingen Germany

10. Group for Neuroimmunology and Imaging German Center for Neurodegenerative Diseases (DZNE) Bonn Germany

11. Department of Physiology and Biochemistry Centre for Molecular Medicine and Biobanking University of Malta Msida Malta

12. Department of Neurology University Medical Center Göttingen University of Göttingen Göttingen Germany

13. Life Sciences and Chemistry Jacobs University of Bremen Bremen Germany

14. Center for Neuropathology and Prion Research Ludwig‐Maximilians‐University Munich Munich Germany

15. Helmholtz Center for Infections Research Braunschweig Germany

Funder

Deutsches Zentrum für Neurodegenerative Erkrankungen

Max-Planck-Gesellschaft

Deutsche Forschungsgemeinschaft

Publisher

EMBO

Subject

Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.201707825

Reference54 articles.

1. Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation

2. Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

3. HDAC inhibitor‐dependent transcriptome and memory reinstatement in cognitive decline models;Benito E;J Clin Invest,2015

4. Formation of large, ion-permeable membrane channels by the matrix protein (porin) of Escherichia coli

5. EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

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