Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors
Author:
Affiliation:
1. Leslie Dan Faculty of Pharmacy University of Toronto Toronto ON Canada
2. Department of Biochemistry University of Toronto Toronto ON Canada
Publisher
EMBO
Subject
Molecular Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.202114002
Reference11 articles.
1. Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche
2. RNF43 is frequently mutated in colorectal and endometrial cancers
3. Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
4. Synthetic lethality as an engine for cancer drug target discovery
5. Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma
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