Targeting TGF βR2‐mutant tumors exposes vulnerabilities to stromal TGF β blockade in pancreatic cancer-Reference-Cited by-同舟云学术

Targeting TGF βR2‐mutant tumors exposes vulnerabilities to stromal TGF β blockade in pancreatic cancer

Published:2019-10-14 Issue:11 Volume:11 Page:
ISSN:1757-4676
Container-title:EMBO Molecular Medicine
language:en
Short-container-title:EMBO Mol Med

Author:

Huang Huocong¹^ORCID,Zhang Yuqing¹²^ORCID,Gallegos Valerie³,Sorrelle Noah¹,Zaid Mohamed Medhat⁴,Toombs Jason¹,Du Wenting¹²,Wright Steven¹,Hagopian Moriah⁵,Wang Zhaoning⁶,Hosein Abdel Nasser⁷,Sathe Adwait Amod⁸,Xing Chao⁸,Koay Eugene J⁴,Driscoll Kyla E⁹,Brekken Rolf A¹²⁵^ORCID

Affiliation:

1. Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical Center Dallas TX USA

2. Cancer Biology Graduate Program University of Texas Southwestern Medical Center Dallas TX USA

3. Department of Biological Sciences University of Texas at El Paso El Paso TX USA

4. Division of Radiation Oncology University of Texas MD Anderson Cancer Center Houston TX USA

5. Department of Surgery University of Texas Southwestern Medical Center Dallas TX USA

6. Department of Molecular Biology University of Texas Southwestern Medical Center Dallas TX USA

7. Division of Hematology and Oncology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX USA

8. McDermott Center of Human Growth and Development University of Texas Southwestern Medical Center Dallas TX USA

9. Eli Lilly and Company Indianapolis IN USA

Funder

Eli Lilly and Company

National Institutes of Health

American Heart Association

Publisher

EMBO

Subject

Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.201910515

Reference53 articles.

1. LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

2. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

3. Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

4. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma

5. STAT3Plays a Critical Role inKRAS-Induced Pancreatic Tumorigenesis

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