Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons-Reference-Cited by-全球学者库

Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons

Published:2022-04-04 Issue:5 Volume:14 Page:
ISSN:1757-4676
Container-title:EMBO Molecular Medicine
language:en
Short-container-title:EMBO Mol Med

Author:

Giehrl‐Schwab Jessica¹²,Giesert Florian¹²^ORCID,Rauser Benedict¹²,Lao Chu Lan³⁴^ORCID,Hembach Sina¹²,Lefort Sandrine⁵,Ibarra Ignacio L⁶^ORCID,Koupourtidou Christina³⁷^ORCID,Luecken Malte Daniel⁶^ORCID,Truong Dong‐Jiunn Jeffery¹²^ORCID,Fischer‐Sternjak Judith³⁴^ORCID,Masserdotti Giacomo³⁴,Prakash Nilima⁸^ORCID,Ninkovic Jovica³⁷^ORCID,Hölter Sabine M¹⁹^ORCID,Vogt Weisenhorn Daniela M¹²,Theis Fabian J⁶¹⁰^ORCID,Götz Magdalena³⁴¹¹^ORCID,Wurst Wolfgang¹²¹¹¹²^ORCID

Affiliation:

1. Institute of Developmental Genetics Helmholtz Center Munich Neuherberg Germany

2. Munich School of Life Sciences Weihenstephan Technical University of Munich Munich Germany

3. Institute of Stem Cell Research Helmholtz Center Munich Neuherberg Germany

4. Physiological Genomics Biomedical Center (BMC) Ludwig‐Maximilians‐Universität (LMU) Planegg‐Martinsried Germany

5. Institute for Diabetes and Obesity Helmholtz Center Munich Neuherberg Germany

6. Institute of Computational Biology Helmholtz Center Munich Neuherberg Germany

7. Department for Cell Biology and Anatomy Biomedical Center Ludwig‐Maximilians‐Universität (LMU) Planegg‐Martinsried Germany

8. Laboratory of Applied Genetics and Stem Cell Biology Department Hamm 2 Hamm‐Lippstadt University of Applied Sciences Hamm Germany

9. German Mouse Clinic Helmholtz Center Munich Neuherberg Germany

10. Department of Mathematics Technical University of Munich Garching Germany

11. Munich Cluster for Systems Neurology (SyNergy) Munich Germany

12. German Center for Neurodegenerative Diseases (DZNE) Site Munich Munich Germany

Funder

Chan Zuckerberg Initiative

Else Kröner-Fresenius-Stiftung

Helmholtz Association

Publisher

EMBO

Subject

Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.202114797

Reference67 articles.

1. Efficient Conversion of Astrocytes to Functional Midbrain Dopaminergic Neurons Using a Single Polycistronic Vector

2. Functional Properties of Neurons Derived from In Vitro Reprogrammed Postnatal Astroglia

3. Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective

4. One step generation of customizable gRNA vectors for multiplex CRISPR approaches through string assembly gRNA cloning (STAgR)

5. Tests to assess motor phenotype in mice: a user's guide

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