Development of a small molecule that corrects misfolding and increases secretion of Z α 1 ‐antitrypsin
Author:
Affiliation:
1. UCL Respiratory Rayne Institute University College London London UK
2. GlaxoSmithKline Cambridge MA USA
3. GlaxoSmithKline Stevenage UK
4. GlaxoSmithKline Paris France
5. Cambridge Institute for Medical Research Cambridgem UK
Funder
GlaxoSmithKline
Medical Research Council
UCLH Biomedical Research Centre
Biotechnology and Biological Sciences Research Council
Publisher
EMBO
Subject
Molecular Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.202013167
Reference46 articles.
1. From haystack to needle: finding value with DNA encoded library technology at GSK
2. Design, synthesis and selection of DNA-encoded small-molecule libraries
3. A Kinetic Mechanism for the Polymerization of α1-Antitrypsin
4. Defining the mechanism of polymerization in the serpinopathies
5. Features and development ofCoot
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