Oral administration of pyrophosphate inhibits connective tissue calcification

Author:

Dedinszki Dóra1,Szeri Flóra1,Kozák Eszter12,Pomozi Viola13,Tőkési Natália1,Mezei Tamás Róbert45,Merczel Kinga1,Letavernier Emmanuel678,Tang Ellie67,Le Saux Olivier3,Arányi Tamás19,Wetering Koen10,Váradi András1ORCID

Affiliation:

1. Institute of Enzymology RCNS Hungarian Academy of Sciences Budapest Hungary

2. Department of Immunology ELTE Budapest Hungary

3. Department of Cell and Molecular Biology John A. Burns School of Medicine University of Hawaii Honolulu HI USA

4. Department of Mathematics and its Applications Central European University Budapest Hungary

5. Alfréd Rényi Institute of Mathematics Hungarian Academy of Sciences Budapest Hungary

6. Sorbonne Universités, UPMC Univ Paris 06, UMR S 1155 Paris France

7. INSERM UMR S 1155 Paris France

8. Physiology Unit AP‐HP Hôpital Tenon Paris France

9. MITOVASC, CNRS UMR 6015 Inserm U1083 University of Angers Angers France

10. Division of Molecular Oncology Netherlands Cancer Institute Amsterdam The Netherlands

Funder

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

Publisher

EMBO

Subject

Molecular Medicine

Reference27 articles.

1. Pseudoxanthoma elasticum-like skin lesions and angioid streaks in β-thalassemia

2. AherrahrouZ(2003)Histological and molecular genetic analysis of mice with genetic predisposition to dystrophic cardiac calcification in response to injury. PhD Dissertation Faculty of Medicine University of Lübeck Germanyhttp://www.zhb.uni-luebeck.de/epubs/ediss2.pdf

3. Mutations in ABCC6 cause pseudoxanthoma elasticum

4. The Level of Hepatic ABCC6 Expression Determines the Severity of Calcification after Cardiac Injury

5. Arterial calcification in mice after freeze-thaw injury

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