SOX 9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis

Author:

Athwal Varinder S12,Pritchett James3,Llewellyn Jessica1,Martin Katherine12,Camacho Elizabeth4,Raza Sayyid MA12,Phythian‐Adams Alexander5,Birchall Lindsay J12,Mullan Aoibheann F12,Su Kim12,Pearmain Laurence12,Dolman Grace6,Zaitoun Abed M7,Friedman Scott L8,MacDonald Andrew5ORCID,Irving William L69,Guha Indra N6,Hanley Neil A12,Piper Hanley Karen12ORCID

Affiliation:

1. Division of Diabetes, Endocrinology and Gastroenterology Faculty of Biology, Medicine & Health Manchester Academic Health Science Centre University of Manchester Manchester UK

2. Research & Innovation Division Central Manchester University Hospitals NHS Foundation Trust Manchester UK

3. School of Healthcare Science Manchester Metropolitan University Manchester UK

4. Centre for Health Economics Institute of Population Health Faculty of Medical & Human Sciences Manchester Academic Health Science Centre University of Manchester Manchester UK

5. Manchester Centre for Collaborative Inflammation Research Faculty of Life Sciences University of Manchester Manchester UK

6. Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK

7. Department of Cellular Pathology Nottingham Digestive Diseases Centre and National Institute of Health Research Biomedical Research Unit in Gastroenterology and Liver Disease University of Nottingham and Nottingham University Hospitals NHS Trust Nottingham UK

8. Division of Liver Diseases Icahn School of Medicine at Mount Sinai New York NY USA

9. School of Life Sciences Nottingham Digestive Diseases Centre and National Institute of Health Research Biomedical Research Unit in Gastroenterology and Liver Disease University of Nottingham and Nottingham University Hospitals NHS Trust Nottingham UK

Funder

Medical Research Council

Wellcome

Kidney Research UK

University of Manchester

Publisher

EMBO

Subject

Molecular Medicine

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