Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma

Author:

Echevarría‐Vargas Ileabett M1,Reyes‐Uribe Patricia I1,Guterres Adam N1,Yin Xiangfan1,Kossenkov Andrew V1,Liu Qin1,Zhang Gao1,Krepler Clemens1,Cheng Chaoran2,Wei Zhi2,Somasundaram Rajasekharan1,Karakousis Giorgos34,Xu Wei3,Morrissette Jennifer JD56,Lu Yiling7,Mills Gordon B7,Sullivan Ryan J8,Benchun Miao8,Frederick Dennie T8,Boland Genevieve9,Flaherty Keith T8,Weeraratna Ashani T1011,Herlyn Meenhard110,Amaravadi Ravi412,Schuchter Lynn M412,Burd Christin E13,Aplin Andrew E14,Xu Xiaowei47,Villanueva Jessie110ORCID

Affiliation:

1. Molecular & Cellular Oncogenesis Program The Wistar Institute Philadelphia PA USA

2. College of Computing Sciences New Jersey Institute of Technology Newark NJ USA

3. Abramson Cancer Center University of Pennsylvania Philadelphia PA USA

4. Department of Surgery Hospital of the University of Pennsylvania Philadelphia PA USA

5. Center for Personalized Diagnostics Hospital of the University of Pennsylvania University of Pennsylvania Philadelphia PA USA

6. Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia PA USA

7. Department of Systems Biology The University of Texas MD Anderson Cancer Center Houston TX USA

8. Massachusetts General Hospital Cancer Center Harvard Medical School Boston MA USA

9. Department of Surgery Massachusetts General Hospital Harvard Medical School Boston MA USA

10. Melanoma Research Center The Wistar Institute Philadelphia PA USA

11. Immunology, Microenvironment and Metastasis Program The Wistar Institute Philadelphia PA USA

12. Department of Medicine Hospital of the University of Pennsylvania Philadelphia PA USA

13. Departments of Molecular Genetics and Cancer Biology and Genetics Ohio State University Columbus OH USA

14. Department of Cancer Biology and Sidney Kimmel Cancer Center Thomas Jefferson University Philadelphia PA USA

Funder

National Cancer Institute

Melanoma Research Alliance

Melanoma Research Foundation

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

National Institutes of Health

American Cancer Society

V Foundation for Cancer Research

Publisher

EMBO

Subject

Molecular Medicine

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