Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component

Author:

Thibault Benoit12ORCID,Ramos‐Delgado Fernanda12,Pons‐Tostivint Elvire12,Therville Nicole12,Cintas Celia12,Arcucci Silvia12,Cassant‐Sourdy Stephanie12,Reyes‐Castellanos Gabriela3,Tosolini Marie1ORCID,Villard Amelie V12,Cayron Coralie12,Baer Romain12,Bertrand‐Michel Justine4,Pagan Delphine1,Ferreira Da Mota Dina15,Yan Hongkai67,Falcomatà Chiara67,Muscari Fabrice15,Bournet Barbara15,Delord Jean‐Pierre15,Aksoy Ezra8,Carrier Alice3ORCID,Cordelier Pierre1,Saur Dieter67ORCID,Basset Celine125,Guillermet‐Guibert Julie12ORCID

Affiliation:

1. Centre de Recherches en Cancérologie de Toulouse Inserm, CNRS Université de Toulouse Toulouse France

2. LABEX TouCAN Toulouse France

3. Aix Marseille Univ, CNRS, INSERM, Institut Paoli‐Calmettes, CRCM Marseille France

4. Lipidomics, I2MC, Inserm Toulouse France

5. Institut Universitaire du Cancer de Toulouse – Oncopole (IUCT‐O) Hopitaux de Toulouse Institut Claudius Regaud Toulouse France

6. Division of Translational Cancer Research German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK) Heidelberg Germany

7. Chair of Translational Cancer Research and Institute of Experimental Cancer Therapy Klinikum rechts der Isar School of Medicine Technische Universität München Munich Germany

8. Centre for Biochemical Pharmacology William Harvey Research Institute Queen Mary University of London London UK

Funder

Fondation de France

Ligue Contre le Cancer

Division of Arctic Sciences

H2020 European Research Council

Publisher

EMBO

Subject

Molecular Medicine

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