A DNA / HDAC dual‐targeting drug CY 190602 with significantly enhanced anticancer potency

Author:

Liu Chuan12,Ding Hongyu1,Li Xiaoxi1,Pallasch Christian P3,Hong Liya4,Guo Dianwu4,Chen Yi5,Wang Difei6,Wang Wei7,Wang Yajie2,Hemann Michael T8,Jiang Hai1

Affiliation:

1. Key Laboratory of Systems Biology, State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

2. Department of Oncology Changhai Hospital Second Military Medical University Shanghai China

3. Clinic for Internal Medicine University Hospital of Cologne Cologne Germany

4. Hangzhou Minsheng Pharma Research Institute Ltd Hangzhou China

5. Crystal Biopharmaceutical LLC Pleasanton CA USA

6. Department of Biochemistry and Molecular & Cellular Biology Georgetown University Medical Center Washington DC USA

7. Department of Chemistry University of New Mexico Albuquerque NM USA

8. The Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology Cambridge MA USA

Publisher

EMBO

Subject

Molecular Medicine

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