The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKC δ‐dependent inhibition of the AKT pathway

Author:

Assad Kahn Suzana1234,Costa Silvia Lima1235,Gholamin Sharareh4,Nitta Ryan T4,Dubois Luiz Gustavo1236,Fève Marie7,Zeniou Maria7,Coelho Paulo Lucas Cerqueira1235,El‐Habr Elias123,Cadusseau Josette8,Varlet Pascale910,Mitra Siddhartha S4,Devaux Bertrand121011,Kilhoffer Marie‐Claude7,Cheshier Samuel H4,Moura‐Neto Vivaldo6,Haiech Jacques7,Junier Marie‐Pierre123,Chneiweiss Hervé123

Affiliation:

1. INSERM UMR‐S 1130 Neuroscience Paris Seine‐IBPS Paris France

2. CNRS UMR 8246 Neuroscience Paris Seine‐IBPS Paris France

3. Sorbonne Universités UPMC Université Paris 06 UMR‐S 8246 Neuroscience Paris Seine‐IBPS Paris France

4. Department of Neurosurgery Institute for Stem Cell Biology and Regenerative Medicine and Division of Pediatric Neurosurgery Lucile Packard Children's Hospital Stanford University Stanford CA USA

5. Neurochemistry and Cell Biology Laboratory Universidade Federal da Bahia Salvador‐Bahia Brazil

6. Instituto Estadual do Cérebro Paulo Niemeyer Rio de Janeiro Brazil

7. Laboratoire d'Innovation Thérapeutique Laboratoire d'Excellence Medalis Faculté de Pharmacie Université de Strasbourg/CNRS UMR7200 Illkirch France

8. UMR INSERM 955‐Team 10 Faculté des Sciences et Technologies UPEC Créteil France

9. Department of Neuropathology Sainte‐Anne Hospital Paris France

10. Paris Descartes University Paris France

11. Department of Neurosurgery Sainte‐Anne Hospital Paris France

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

EMBO

Subject

Molecular Medicine

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