Targeting the LOX / hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

Author:

Miller Bryan W1,Morton Jennifer P1,Pinese Mark2,Saturno Grazia3,Jamieson Nigel B4,McGhee Ewan1,Timpson Paul2,Leach Joshua1,McGarry Lynn1,Shanks Emma1,Bailey Peter5,Chang David5,Oien Karin5,Karim Saadia1,Au Amy1,Steele Colin1,Carter Christopher Ross4,McKay Colin4,Anderson Kurt1,Evans Thomas R Jeffry15,Marais Richard3,Springer Caroline6,Biankin Andrew5,Erler Janine T7,Sansom Owen J1

Affiliation:

1. Cancer Research UK Beatson Institute Garscube Estate Glasgow UK

2. The Garvan Institute of Medical Research Sydney NSW Australia

3. Cancer Research UK Manchester Institute Withington Manchester UK

4. West of Scotland Pancreatic Unit Glasgow Royal Infirmary Glasgow UK

5. Institute of Cancer Sciences University of Glasgow Garscube Estate Glasgow UK

6. Institute of Cancer Research London UK

7. Biotech Research & Innovation Centre (BRIC) University of Copenhagen Copenhagen (UCPH) Denmark

Funder

Novo Nordisk Foundation (Hallas Møller Stipend)

Cancer Research UK

Pancreatic Cancer Research Fund

Publisher

EMBO

Subject

Molecular Medicine

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