Human ALPI deficiency causes inflammatory bowel disease and highlights a key mechanism of gut homeostasis

Author:

Parlato Marianna12,Charbit‐Henrion Fabienne1234,Pan Jie5,Romano Claudio26,Duclaux‐Loras Rémi123,Le Du Marie‐Helene7,Warner Neil5,Francalanci Paola8,Bruneau Julie39,Bras Marc10,Zarhrate Mohammed11,Bègue Bernadette12,Guegan Nicolas13,Rakotobe Sabine12,Kapel Nathalie12,De Angelis Paola8,Griffiths Anne M5,Fiedler Karoline5ORCID,Crowley Eileen5,Ruemmele Frank1234,Muise Aleixo M51314,Cerf‐Bensussan Nadine123ORCID

Affiliation:

1. INSERM, UMR1163 Laboratory of Intestinal Immunity and Institut Imagine Paris France

2. GENIUS group from ESPGHAN

3. Université Paris Descartes‐Sorbonne Paris Cité Paris France

4. Department of Pediatric Gastroenterology Assistance Publique‐Hôpitaux de Paris Hôpital Necker‐Enfants Malades Paris France

5. SickKids Inflammatory Bowel Disease Center and Cell Biology Program Research Institute Hospital for Sick Children Toronto ON Canada

6. Unit of Pediatrics Department of Human Pathology in Adulthood and Childhood “G. Barresi” University of Messina Messina Italy

7. Department of Biochemistry, Biophysics and Structural Biology Institute for Integrative Biology of the Cell (I2BC) CEA UMR 9198 CNRS Université Paris‐Sud Gif‐sur‐Yvette France

8. Digestive Endoscopy and Surgery Unit and Pathology Unit Bambino Gesù Children Hospital IRCCS Rome Italy

9. Department of Pathology Necker‐Enfants Malades Hospital Assistance Publique‐Hôpitaux de Paris Paris France

10. Bioinformatics Platform Université Paris‐Descartes‐Paris Sorbonne Centre and Institut Imagine Paris France

11. Genomic Platform INSERM, UMR1163 Imagine Institute Paris Descartes‐Sorbonne Paris Cite University Paris France

12. Department of Functional Coprology Pitié Salpêtrière Hospital Assistance publique‐Hôpitaux de Paris (AP‐HP) Paris France

13. Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Hospital for Sick Children University of Toronto Toronto ON Canada

14. Department of Biochemistry Institute of Medical Science University of Toronto Toronto ON Canada

Funder

H2020 European Research Council

Agence Nationale de la Recherche

Leona M. and Harry B. Helmsley Charitable Trust

Canadian Institutes of Health Research

Publisher

EMBO

Subject

Molecular Medicine

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