Nuclease‐independent functions of <scp>RAG1</scp> direct distinct <scp>DNA</scp> damage responses in B cells-Reference-Cited by-同舟云学术

Nuclease‐independent functions of RAG1 direct distinct DNA damage responses in B cells

Published:2022-11-16 Issue:1 Volume:24 Page:
ISSN:1469-221X
Container-title:EMBO reports
language:en
Short-container-title:EMBO Reports

Author:

Johnston Rachel¹,Mathias Brendan¹,Crowley Stephanie J¹^ORCID,Schmidt Haley A¹,White Lynn S¹,Mosammaparast Nima²^ORCID,Green Abby M¹^ORCID,Bednarski Jeffrey J¹^ORCID

Affiliation:

1. Department of Pediatrics Washington University School of Medicine St. Louis MO USA

2. Department of Pathology and Immunology Washington University School of Medicine St. Louis MO USA

Funder

Alvin J. Siteman Cancer Center

American Cancer Society

American Society of Hematology

Children's Discovery Institute

Foundation for Barnes-Jewish Hospital

Gabrielle's Angel Foundation for Cancer Research

National Cancer Institute

National Institute of Allergy and Infectious Diseases

St. Louis Children's Hospital

U.S. Department of Defense

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embr.202255429

Reference67 articles.

1. RAG1 and RAG2 Form a Stable Postcleavage Synaptic Complex with DNA Containing Signal Ends in V(D)J Recombination

2. Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System

3. Phosphorylation and Rapid Relocalization of 53BP1 to Nuclear Foci upon DNA Damage

4. Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways

5. Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

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