Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2

Author:

Vaes Nathalie1ORCID,Schonkeren Simone L1ORCID,Rademakers Glenn1,Holland Amy M1,Koch Alexander1,Gijbels Marion J123,Keulers Tom G4,de Wit Meike56,Moonen Laura1,Van der Meer Jaleesa R M1,van den Boezem Edith1,Wolfs Tim G A M7,Threadgill David W89,Demmers Jeroen10,Fijneman Remond J A6,Jimenez Connie R5,Vanden Berghe Pieter11,Smits Kim M1,Rouschop Kasper M A4,Boesmans Werend112ORCID,Hofstra Robert M W13,Melotte Veerle113ORCID

Affiliation:

1. Department of Pathology GROW–School for Oncology and Developmental Biology Maastricht University Medical Center Maastricht The Netherlands

2. Department of Molecular Genetics Cardiovascular Research Institute Maastricht (CARIM) Maastricht The Netherlands

3. Department of Medical Biochemistry Academic Medical Center Amsterdam The Netherlands

4. Department of Radiotherapy GROW‐School for Oncology and Developmental Biology and Comprehensive Cancer Center Maastricht MUMC+ Maastricht University Maastricht The Netherlands

5. Department of Medical Oncology and Oncoproteomics Laboratory Cancer Center Amsterdam Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam The Netherlands

6. Department of Pathology Netherlands Cancer Institute Amsterdam The Netherlands

7. Department of Pediatrics GROW‐School for Oncology and Developmental Biology Maastricht University Maastricht The Netherlands

8. Department of Molecular and Cellular Medicine Texas A&M University Health Science Center College Station TX USA

9. Department of Biochemistry and Biophysics Texas A&M University College Station TX USA

10. Proteomics Center Erasmus University Medical Center Rotterdam The Netherlands

11. Laboratory for Enteric Neuroscience (LENS) and Translational Research Center for Gastrointestinal Disorders (TARGID) Department of Chronic Diseases, Metabolism and Ageing KU Leuven Leuven Belgium

12. Biomedical Research Institute (BIOMED) Hasselt University Hasselt Belgium

13. Department of Clinical Genetics Erasmus University Medical Center Rotterdam The Netherlands

Funder

KWF Kankerbestrijding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

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