Intracellular growth of Brucella is mediated by Dps‐dependent activation of ferritinophagy

Author:

Hop Huynh Tan1ORCID,Huy Tran Xuan Ngoc2ORCID,Lee Hu Jang2ORCID,Kim Suk2ORCID

Affiliation:

1. University Center for Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan

2. College of Veterinary Medicine Gyeongsang National University Jinju Korea

Abstract

AbstractBacteria of the genus Brucella cause brucellosis, one of the world's most common zoonotic diseases. A major contributor to Brucella's virulence is the ability to circumvent host immune defense mechanisms. Here, we find that the DNA‐binding protein Dps from Brucella is secreted within the macrophage cytosol, modulating host iron homeostasis and mediating intracellular growth of Brucella. In addition to dampening iron‐dependent production of reactive oxygen species (ROS), a key immune effector required for immediate bacterial clearance, cytosolic Dps mediates ferritinophagy activation to elevate intracellular free‐iron levels, thereby promoting Brucella growth and inducing host cell necrosis. Inactivation of the ferritinophagy pathway by Ncoa4 gene knockout significantly inhibits intracellular growth of Brucella and host cell death. Our study uncovers an unconventional role of bacterial Dps, identifying a crucial virulence mechanism used by Brucella to adapt to the harsh environment inside macrophages.

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Biochemistry

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