Asexuality in Drosophila juvenile males is organizational and independent of juvenile hormone

Author:

Ji Xiaoxiao1,Li Xiaolong1,Wang Lin1,Liu Suning2,Jiang Xinyu1,Pan Yufeng13ORCID

Affiliation:

1. The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology Southeast University Nanjing China

2. Guangmeiyuan R&D Center, Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology South China Normal University Meizhou China

3. Co‐innovation Center of Neuroregeneration Nantong University Nantong China

Abstract

AbstractSexuality is generally prevented in newborns and arises with organizational rewiring of neural circuitry and optimization of fitness for reproduction competition. Recent studies reported that sex circuitry in Drosophila melanogaster is developed in juvenile males but functionally inhibited by juvenile hormone (JH). Here, we find that the fly sex circuitry, mainly expressing the male‐specific fruitless (fruM) and/or doublesex (dsx), is organizationally undeveloped and functionally inoperative in juvenile males. Artificially activating all fruM neurons induces substantial courtship in solitary adult males but not in juvenile males. Synaptic transmissions between major courtship regulators and all dsx neurons are strong in adult males but either weak or undetectable in juvenile males. We further find that JH does not inhibit male courtship in juvenile males but instead promotes courtship robustness in adult males. Our results indicate that the transition to sexuality from juvenile to adult flies requires organizational rewiring of neural circuitry.

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Biochemistry

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1. Where does mating drive come from?;EMBO reports;2023-08-02

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