RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4‐mediated ubiquitination of HES1

Author:

Papaspyropoulos Angelos123ORCID,Angelopoulou Andriani23,Mourkioti Ioanna2,Polyzou Aikaterini2,Pankova Daniela1ORCID,Toskas Konstantinos1,Lanfredini Simone1,Pantazaki Anastasia A4ORCID,Lagopati Nefeli23,Kotsinas Athanassios2,Evangelou Konstantinos2,Chronopoulos Efstathios5,O’Neill Eric1ORCID,Gorgoulis Vassilis23678ORCID

Affiliation:

1. Department of Oncology University of Oxford Oxford UK

2. Molecular Carcinogenesis Group Department of Histology and Embryology School of Medicine National Kapodistrian University of Athens (NKUA) Athens Greece

3. Biomedical Research Foundation Academy of Athens Athens Greece

4. Laboratory of Biochemistry Department of Chemistry Aristotle University of Thessaloniki Thessaloniki Greece

5. Laboratory for Research of the Musculoskeletal System KAT General Hospital School of Medicine National and Kapodistrian University of Athens Athens Greece

6. Molecular and Clinical Cancer Sciences Manchester Cancer Research Centre Manchester Academic Health Sciences Centre University of Manchester Manchester UK

7. Center for New Biotechnologies and Precision Medicine Medical School National and Kapodistrian University of Athens Athens Greece

8. Faculty of Health and Medical Sciences University of Surrey Surrey UK

Funder

Cancer Research UK

Medical Research Council

Kidani Memorial Trust

Federal Agency for Scientific Organizations

Science Foundation Ireland

State Scholarships Foundation

Hellenic Foundation for Research and Innovation

Marie Curie

General Secretariat for Research and Technology

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

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