Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation

Author:

Betzer Cristine12ORCID,Lassen Louise Berkhoudt12,Olsen Anders3,Kofoed Rikke Hahn12,Reimer Lasse12,Gregersen Emil12,Zheng Jin12,Calì Tito4,Gai Wei‐Ping5,Chen Tong6,Moeller Arne17,Brini Marisa8,Fu Yuhong9,Halliday Glenda9,Brudek Tomasz10,Aznar Susana10,Pakkenberg Bente10,Andersen Jens Peter2,Jensen Poul Henning12ORCID

Affiliation:

1. Danish Research Institute of Translational Neuroscience – DANDRITE Aarhus University Aarhus Denmark

2. Department of Biomedicine Aarhus University Aarhus Denmark

3. Department of Molecular Biology and Genetics Aarhus University Aarhus Denmark

4. Department of Biomedical Sciences University of Padova Padova Italy

5. Neuropathological Laboratory Department of Medicine Center for Neurological Diseases University of Adelaide Adelaide SA Australia

6. Department of Medical Biochemistry School of Medicine Flinders University Bedford Park SA Australia

7. Department of Structural Biology Max Plank Institute of Biophysics Frankfurt Germany

8. Department of Biology University of Padova Padova Italy

9. Brain & Mind Centre Sydney Medical School The University of Sydney Sydney NSW Australia

10. Research Laboratory for Stereology and Neuroscience Bispebjerg‐Frederiksberg Hospital Copenhagen Denmark

Funder

National Institutes of Health

National Health and Medical Research Council

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

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