The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation

Author:

Yang Jing1,Wei Ping2,Barbi Joseph3ORCID,Huang Qianru1,Yang Evan4,Bai Yakun5,Nie Jia16,Gao Yanhang7,Tao Jinhui4,Lu Ying8,Xie Chichu9,Hou Xiaoxia10,Ren Jiazi6,Wu Xingmei11,Meng Jian8,Zhang Ying12,Fu Juan4,Kou Wei2,Gao Yayi16,Chen Zuojia16,Liang Rui16,Tsun Andy16,Li Dan16,Guo Wenzhi5,Zhang Shuijun5,Zheng Song‐Guo9,Niu Junqi7,Galardy Paul12,Tong Xuemei8,Shi Guochao10,Li Huabin11ORCID,Pan Fan413ORCID,Li Bin16510ORCID

Affiliation:

1. Shanghai Institute of Immunology and Department of Immunology and Microbiology Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong University Shanghai China

2. Department of Otolaryngology Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders (Chongqing) China International Science and Technology Cooperation base of Child Development and Critical Disorders Children's Hospital of Chongqing Medical University Chongqing China

3. Department of Immunology Roswell Park Comprehensive Cancer Center Buffalo NY USA

4. Immunology and Hematopoiesis Division Department of Oncology Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore MD USA

5. Henan Key Laboratory of Digestive Organ Transplantation Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou University Henan China

6. Key Laboratory of Molecular Virology & Immunology CAS Center for Excellence in Molecular Cell Science Unit of Molecular Immunology Institut Pasteur of Shanghai Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

7. Department of Hepatology First Hospital Jilin University Changchun, Jilin China

8. Shanghai Key Laboratory for Tumor Microenvironment and Inflammation Department of Biochemistry and Molecular Cell Biology Shanghai Jiao Tong University School of Medicine Shanghai China

9. Division of Rheumatology Department of Medicine Penn State Hershey College of Medicine Hershey PA USA

10. Department of Pulmonary and Critical Care Medicine Institute of Respiratory Diseases Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

11. ENT Department, Affiliated Eye and ENT Hospital Fudan University Shanghai China

12. Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester MN USA

13. Institutes of Advanced Technology Chinese Academy of Science Shenzhen China

Funder

Melanoma Research Foundation

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

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