SIRT 5 inhibits peroxisomal ACOX 1 to prevent oxidative damage and is downregulated in liver cancer

Author:

Chen Xiu‐Fei123,Tian Meng‐Xin45ORCID,Sun Ren‐Qiang123,Zhang Meng‐Li123,Zhou Li‐Sha123,Jin Lei45,Chen Lei‐Lei123,Zhou Wen‐Jie123,Duan Kun‐Long123,Chen Yu‐Jia123,Gao Chao123,Cheng Zhou‐Li123,Wang Fang123,Zhang Jin‐Ye123,Sun Yi‐Ping123,Yu Hong‐Xiu123,Zhao Yu‐Zheng6,Yang Yi6,Liu Wei‐Ren45,Shi Ying‐Hong45,Xiong Yue1237ORCID,Guan Kun‐Liang1238ORCID,Ye Dan1239ORCID

Affiliation:

1. Molecular and Cell Biology Lab Institute of Biomedical Sciences Shanghai Medical College Shanghai China

2. Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Fudan University Shanghai China

3. State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and Development School of Life Sciences Fudan University Shanghai China

4. Department of Liver Surgery Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China

5. Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Shanghai China

6. School of Pharmacy East China University of Science and Technology Shanghai China

7. Lineberger Comprehensive Cancer Center Department of Biochemistry and Biophysics University of North Carolina at Chapel Hill Chapel Hill NC USA

8. Department of Pharmacology and Moores Cancer Center University of California San Diego La Jolla CA USA

9. Department of General Surgery Huashan Hospital Fudan University Shanghai China

Funder

National Natural Science Foundation of China

National Cancer Institute

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

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