The fungal ligand chitin directly binds TLR 2 and triggers inflammation dependent on oligomer size

Author:

Fuchs Katharina1,Cardona Gloria Yamel1,Wolz Olaf‐Oliver1,Herster Franziska1,Sharma Lokesh2,Dillen Carly A3,Täumer Christoph4,Dickhöfer Sabine1,Bittner Zsofia1,Dang Truong‐Minh1,Singh Anurag5,Haischer Daniel6,Schlöffel Maria A6,Koymans Kirsten J7,Sanmuganantham Tharmila1,Krach Milena1,Roger Thierry8,Le Roy Didier8,Schilling Nadine A9,Frauhammer Felix1011,Miller Lloyd S3,Nürnberger Thorsten6,LeibundGut‐Landmann Salomé12,Gust Andrea A6ORCID,Macek Boris4,Frank Martin13,Gouttefangeas Cécile1,Dela Cruz Charles S2,Hartl Dominik514,Weber Alexander NR1ORCID

Affiliation:

1. Department of Immunology University of Tübingen Tübingen Germany

2. Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine Department of Microbial Pathogenesis Center for Pulmonary Infection Research and Infection (CPIRT) New Haven CT USA

3. Department of Dermatology Johns Hopkins University School of Medicine Baltimore MD USA

4. Department of Quantitative Proteomics and Proteome Center University of Tübingen Tübingen Germany

5. University Children's Hospital and Interdisciplinary Center for Infectious Diseases University of Tübingen Tübingen Germany

6. Center for Plant Molecular Biology University of Tübingen Tübingen Germany

7. Department of Medical Microbiology University Medical Center Utrecht CX Utrecht The Netherlands

8. Infectious Diseases Service Lausanne University Hospital Epalinges Switzerland

9. Institute of Organic Chemistry University of Tübingen Tübingen Germany

10. Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany

11. Department of Dermatology Heidelberg University Heidelberg Germany

12. Section of Immunology Vetsuisse Faculty University of Zürich Zürich Switzerland

13. Biognos AB Göteborg Sweden

14. Roche Pharma Research & Early Development (pRED) Immunology, Inflammation and Infectious Diseases (I3) Discovery and Translational Area Roche Innovation Center Basel Basel Switzerland

Funder

Eberhard Karls Universität Tübingen

Deutsche Forschungsgemeinschaft

National Institutes of Health

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

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