Affiliation:
1. Kennedy Institute of Rheumatology University of Oxford Oxford UK
2. Botnar Institute for Musculoskeletal Sciences, NDORMS University of Oxford Oxford UK
3. Max Delbrück Center Berlin Germany
Abstract
AbstractOver the recent years, it has become apparent that a deeper understanding of cell‐to‐cell and organ‐to‐organ communication is necessary to fully comprehend both homeostatic and pathological states. Autophagy is indispensable for cellular development, function, and homeostasis. A crucial aspect is that autophagy can also mediate these processes through its secretory role. The autophagy‐derived secretome relays its extracellular signals in the form of nutrients, proteins, mitochondria, and extracellular vesicles. These crosstalk mediators functionally shape cell fate decisions, tissue microenvironment and systemic physiology. The diversity of the secreted cargo elicits an equally diverse type of responses, which span over metabolic, inflammatory, and structural adaptations in disease and homeostasis. We review here the emerging role of the autophagy‐derived secretome in the communication between different cell types and organs and discuss the mechanisms involved.
Funder
Clarendon Fund
Kennedy Trust for Rheumatology Research
Medical Research Council
Versus Arthritis
Wellcome Trust
Subject
Genetics,Molecular Biology,Biochemistry
Cited by
7 articles.
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