Affiliation:
1. Peter MacCallum Cancer Centre Melbourne Vic Australia
2. Sir Peter MacCallum Department of Oncology The University of Melbourne Melbourne Vic Australia
3. Kings College London Randall Centre for Cell & Molecular Biophysics London UK
4. Department of Anatomy and Physiology The University of Melbourne Melbourne Vic Australia
Abstract
AbstractIn this study, we found that in the adipose tissue of wildtype animals, insulin and TGF‐β signalling converge via a BMP antagonist short gastrulation (sog) to regulate ECM remodelling. In tumour bearing animals, Sog also modulates TGF‐β signalling to regulate ECM accumulation in the fat body. TGF‐β signalling causes ECM retention in the fat body and subsequently depletes muscles of fat body‐derived ECM proteins. Activation of insulin signalling, inhibition of TGF‐β signalling, or modulation of ECM levels via SPARC, Rab10 or Collagen IV in the fat body, is able to rescue tissue wasting in the presence of tumour. Together, our study highlights the importance of adipose ECM remodelling in the context of cancer cachexia.
Funder
National Health and Medical Research Council
Peter MacCallum Foundation
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,Biochemistry
Cited by
4 articles.
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