The functional significance of mitochondrial respiratory chain supercomplexes

Author:

Kohler Andreas12ORCID,Barrientos Antoni34ORCID,Fontanesi Flavia4ORCID,Ott Martin15ORCID

Affiliation:

1. Department of Biochemistry and Biophysics Stockholm University Stockholm Sweden

2. Institute of Molecular Biosciences University of Graz Graz Austria

3. Department of Neurology, Miller School of Medicine University of Miami Miami FL USA

4. Department of Biochemistry and Molecular Biology, Miller School of Medicine University of Miami Miami FL USA

5. Department of Medical Biochemistry and Cell Biology University of Gothenburg Gothenburg Sweden

Abstract

AbstractThe mitochondrial respiratory chain (MRC) is a key energy transducer in eukaryotic cells. Four respiratory chain complexes cooperate in the transfer of electrons derived from various metabolic pathways to molecular oxygen, thereby establishing an electrochemical gradient over the inner mitochondrial membrane that powers ATP synthesis. This electron transport relies on mobile electron carries that functionally connect the complexes. While the individual complexes can operate independently, they are in situ organized into large assemblies termed respiratory supercomplexes. Recent structural and functional studies have provided some answers to the question of whether the supercomplex organization confers an advantage for cellular energy conversion. However, the jury is still out, regarding the universality of these claims. In this review, we discuss the current knowledge on the functional significance of MRC supercomplexes, highlight experimental limitations, and suggest potential new strategies to overcome these obstacles.

Funder

Austrian Science Fund

Army Research Office

National Institutes of Health

Knut och Alice Wallenbergs Stiftelse

Vetenskapsrådet

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Biochemistry

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