Targeting the Warburg effect via LDHA inhibition engages ATF 4 signaling for cancer cell survival-Reference-Cited by-同舟云学术

Targeting the Warburg effect via LDHA inhibition engages ATF 4 signaling for cancer cell survival

Published:2018-09-12 Issue:20 Volume:37 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Pathria Gaurav¹^ORCID,Scott David A¹,Feng Yongmei¹,Sang Lee Joo²,Fujita Yu¹,Zhang Gao³,Sahu Avinash D⁴,Ruppin Eytan²^ORCID,Herlyn Meenhard³,Osterman Andrei L¹,Ronai Ze'ev A¹⁵^ORCID

Affiliation:

1. Tumor Initiation and Maintenance Program Cancer Center Sanford Burnham Prebys Medical Discovery Institute La Jolla CA USA

2. Cancer Data Science Lab (CDSL) National Cancer Institute National Institute of Health Bethesda MD USA

3. Molecular and Cellular Oncogenesis Program and Melanoma Research Center The Wistar Institute Philadelphia PA USA

4. Harvard School of Public Health & Massachusetts General Hospital Boston MA USA

5. Technion Integrated Cancer Center Faculty of Medicine Technion, Israel Institute of Technology Haifa Israel

Funder

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

National Cancer Institute

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201899735

Reference46 articles.

1. Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

2. Regulation of mTORC1 by amino acids

3. Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress

4. Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

5. LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

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