Homeostatic and pathogenic roles of GM 3 ganglioside molecular species in TLR 4 signaling in obesity

Author:

Kanoh Hirotaka1,Nitta Takahiro1,Go Shinji1,Inamori Kei‐ichiro1,Veillon Lucas1,Nihei Wataru1,Fujii Mayu2,Kabayama Kazuya2,Shimoyama Atsushi2,Fukase Koichi2,Ohto Umeharu3,Shimizu Toshiyuki3,Watanabe Taku4,Shindo Hiroki4,Aoki Sorama4ORCID,Sato Kenichi4,Nagasaki Mika5,Yatomi Yutaka6,Komura Naoko7,Ando Hiromune7,Ishida Hideharu78,Kiso Makoto9,Natori Yoshihiro10,Yoshimura Yuichi10,Zonca Asia11,Cattaneo Anna11,Letizia Marilena11,Ciampa Maria11,Mauri Laura11,Prinetti Alessandro11,Sonnino Sandro11,Suzuki Akemi1,Inokuchi Jin‐ichi1ORCID

Affiliation:

1. Division of Glycopathology Institute of Molecular Biomembrane and Glycobiology Tohoku Medical and Pharmaceutical University Sendai Japan

2. Department of Chemistry Graduate School of Science Osaka University Osaka Japan

3. Graduate School of Pharmaceutical Sciences University of Tokyo Tokyo Japan

4. Medical and Pharmaceutical Information Science Tohoku Medical and Pharmaceutical University Sendai Japan

5. Department of Cardiovascular Medicine and Computational Diagnostic Radiology & Preventive Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan

6. Department of Clinical Laboratory Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan

7. Center for Highly Advanced Integration of Nano and Life Sciences (G‐CHAIN) Gifu University Gifu Japan

8. Department of Applied Bio‐organic Chemistry Faculty of Applied Biological Sciences Gifu University Gifu Japan

9. Organization for Research and Community Development Gifu University Gifu Japan

10. Division of Organic and Pharmaceutical Chemistry Tohoku Medical and Pharmaceutical University Sendai Japan

11. Department of Medical Biotechnology and Translational Medicine University of Milan Milano Italy

Funder

Japan Society for the Promotion of Science

Takeda Science Foundation

Fugaku Trust for Medicinal Research

Mizutani Foundation for Glycoscience

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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