Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes

Author:

Jiang Zhe1ORCID,Li Huiqin1,Schroer Stephanie A1,Voisin Veronique2,Ju YoungJun1,Pacal Marek34,Erdmann Natalie5ORCID,Shi Wei1,Chung Philip E D14ORCID,Deng Tao1,Chen Nien‐Jung5ORCID,Ciavarra Giovanni14,Datti Alessandro67ORCID,Mak Tak W5,Harrington Lea8ORCID,Dick Frederick A9,Bader Gary D2ORCID,Bremner Rod34ORCID,Woo Minna110,Zacksenhaus Eldad1410ORCID

Affiliation:

1. Max Bell Research Centre Toronto General Research Institute University Health Network Toronto ON Canada

2. The Donnelly Centre Department of Molecular Genetics University of Toronto Toronto ON Canada

3. Lunenfeld Tanenbaum Research Institute – Sinai Health System Mount Sinai Hospital Department of Ophthalmology and Vision Science University of Toronto Toronto ON Canada

4. Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada

5. Campbell Family Institute for Breast Cancer Research Princess Margaret Hospital Toronto ON Canada

6. Department of Agriculture, Food, and Environmental Sciences University of Perugia Perugia Italy

7. Network Biology Collaborative Centre SMART Laboratory for High‐Throughput Screening Programs Mount Sinai Hospital Toronto ON Canada

8. Department of Medicine Institute for Research in Immunology and Cancer University of Montreal Montreal QC Canada

9. Department of Biochemistry Western University London ON Canada

10. Department of Medicine University of Toronto Toronto ON Canada

Funder

National Institutes of Health

Canadian Institutes of Health Research

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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