An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣membrane-Reference-Cited by-同舟云学术

An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣membrane

Published:2021-06-08 Issue:14 Volume:40 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Lv Fujiao¹²,Qi Fei³,Zhang Zhi³,Wen Maorong¹,Kale Justin⁴^ORCID,Piai Alessandro⁵^ORCID,Du Lingyu¹,Wang Shuqing⁶,Zhou Liujuan¹²,Yang Yaqing¹²,Wu Bin⁷,Liu Zhijun⁷,Rosario Juan³,Pogmore Justin⁴,Chou James J⁵,Andrews David W⁴^ORCID,Lin Jialing³⁸^ORCID,OuYang Bo¹²^ORCID

Affiliation:

1. State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell Biology CAS Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Shanghai China

2. University of Chinese Academy of Sciences Beijing China

3. Department of Biochemistry and Molecular Biology University of Oklahoma Health Sciences Center Oklahoma City OK USA

4. Biological Sciences Sunnybrook Research Institute University of Toronto Toronto ON Canada

5. Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA USA

6. School of Pharmacy Tianjin Medical University Tianjin China

7. National Facility for Protein Science in Shanghai Chinese Academy of Sciences Shanghai China

8. Stephenson Cancer Center Oklahoma City OK USA

Funder

National Key Research and Development Program of China Stem Cell and Translational Research

Oklahoma Center for the Advancement of Science and Technology

Presbyterian Health Foundation

Canadian Institutes of Health Research

National Institutes of Health

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2020106438

Reference52 articles.

1. Pores of No Return

2. Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

3. The program XEASY for computer-supported NMR spectral analysis of biological macromolecules

4. Simulated annealing with restrained molecular dynamics using a flexible restraint potential: Theory and evaluation with simulated NMR constraints

5. Topology of active, membrane-embedded Bax in the context of a toroidal pore

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