NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor-Reference-Cited by-同舟云学术

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

Published:2019-12-23 Issue:3 Volume:39 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Novellasdemunt Laura¹,Kucharska Anna¹,Jamieson Cara²,Prange‐Barczynska Maria¹,Baulies Anna¹,Antas Pedro¹,van der Vaart Jelte³,Gehart Helmuth³,Maurice Madelon M²,Li Vivian SW¹^ORCID

Affiliation:

1. Stem Cell and Cancer Biology Laboratory The Francis Crick Institute London UK

2. Oncode Institute and Department of Cell Biology Center for Molecular Medicine University Medical Center Utrecht Utrecht The Netherlands

3. Hubrecht Institute Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht Utrecht The Netherlands

Funder

Medical Research Council

Wellcome Trust

ZonMw

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Cancer Research UK

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2019102771

Reference54 articles.

1. β-catenin is a target for the ubiquitin–proteasome pathway

2. SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization

3. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells

4. Identification of stem cells in small intestine and colon by marker gene Lgr5

5. Crypt stem cells as the cells-of-origin of intestinal cancer

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