Attenuation of c GAS ‐ STING signaling is mediated by a p62/ SQSTM 1‐dependent autophagy pathway activated by TBK1

Author:

Prabakaran Thaneas12,Bodda Chiranjeevi123,Krapp Christian12,Zhang Bao‐cun12,Christensen Maria H12,Sun Chenglong12,Reinert Line12,Cai Yujia12,Jensen Søren B12,Skouboe Morten K12,Nyengaard Jens R4,Thompson Craig B5,Lebbink Robert Jan6,Sen Ganes C7,Loo Geert89,Nielsen Rikke1,Komatsu Masaaki10,Nejsum Lene N4,Jakobsen Martin R12,Gyrd‐Hansen Mads3ORCID,Paludan Søren R12ORCID

Affiliation:

1. Department of Biomedicine Aarhus University Aarhus Denmark

2. Aarhus Research Center for Innate Immunity Aarhus University Aarhus Denmark

3. Nuffield Department of Medicine Ludwig Institute for Cancer Research University of Oxford Oxford UK

4. Department of Clinical Medicine Aarhus University Aarhus Denmark

5. Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY USA

6. Medical Microbiology University Medical Center Utrecht The Netherlands

7. Department of Immunology Lerner Research Institute Cleveland Clinic Cleveland OH USA

8. Inflammation Research Center VIB Ghent Belgium

9. Department of Biomedical Molecular Biology Ghent University Ghent Belgium

10. Department of Biochemistry Niigata University Graduate School of Medical and Dental Sciences Niigata Japan

Funder

Aarhus Universitets Forskningsfond

Villum Fonden

Wellcome Trust

Sundhed og Sygdom, Det Frie Forskningsråd

Novo Nordisk Fonden

Lundbeckfonden

Seventh Framework Programme

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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