Attenuation of <scp>SARS‐CoV</scp> ‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases-Reference-Cited by-同舟云学术

Attenuation of SARS‐CoV ‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases

Published:2022-07-25 Issue:17 Volume:41 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:The EMBO Journal

Author:

Bergant Valter¹^ORCID,Yamada Shintaro²,Grass Vincent¹^ORCID,Tsukamoto Yuta²^ORCID,Lavacca Teresa¹^ORCID,Krey Karsten¹^ORCID,Mühlhofer Maria‐Teresa¹,Wittmann Sabine³,Ensser Armin³,Herrmann Alexandra³,vom Hemdt Anja⁴^ORCID,Tomita Yuriko⁵,Matsuyama Shutoku⁵,Hirokawa Takatsugu⁶⁷⁸,Huang Yiqi¹^ORCID,Piras Antonio¹,Jakwerth Constanze A⁹^ORCID,Oelsner Madlen⁹,Thieme Susanne¹⁰,Graf Alexander¹⁰,Krebs Stefan¹⁰,Blum Helmut¹⁰^ORCID,Kümmerer Beate M⁴¹¹^ORCID,Stukalov Alexey¹,Schmidt‐Weber Carsten B⁹^ORCID,Igarashi Manabu¹²¹³,Gramberg Thomas³^ORCID,Pichlmair Andreas¹¹⁴^ORCID,Kato Hiroki²^ORCID

Affiliation:

1. Institute of Virology, School of Medicine Technical University of Munich (TUM) Munich Germany

2. Institute of Cardiovascular Immunology, Medical Faculty University Hospital Bonn (UKB) Bonn Germany

3. Institute of Clinical and Molecular Virology Friedrich‐Alexander University Erlangen‐Nürnberg Erlangen Germany

4. Institute of Virology, Medical Faculty University of Bonn Bonn Germany

5. Department of Virology III National Institute of Infectious Diseases (NIID) Tokyo Japan

6. Transborder Medical Research Center University of Tsukuba Tsukuba Japan

7. Division of Biomedical Science University of Tsukuba Tsukuba Japan

8. Cellular and Molecular Biotechnology Research Institute National Institute of Advanced Industrial Science and Technology Tokyo Japan

9. Center for Allergy & Environment (ZAUM) Technical University of Munich (TUM) and Helmholtz Center Munich, German Research Center for Environmental Health Member of the German Center for Lung Research (DZL), CPC‐M Munich Germany

10. Laboratory for functional genome analysis (LAFUGA), Gene Centre Ludwig Maximilian University of Munich (LMU) Munich Germany

11. German Center for Infection Research (DZIF), Bonn‐Cologne Partner Site Bonn Germany

12. International Collaboration Unit, International Institute for Zoonosis Control Hokkaido University Sapporo Japan

13. Division of Global Epidemiology, International Institute for Zoonosis Control Hokkaido University Sapporo Japan

14. German Center for Infection Research (DZIF), Munich partner site Munich Germany

Funder

Bayerisches Staatsministerium für Bildung und Kultus, Wissenschaft und Kunst

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Infektionsforschung

European Research Council

Helmholtz-Gemeinschaft

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2022111608

Reference127 articles.

1. Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations

2. Dysregulation of type I interferon responses in COVID-19

3. Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase

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5. Identification of naphthyridine and quinoline derivatives as potential Nsp16‐Nsp10 inhibitors: a pharmacoinformatics study;Aldahham BJM;J Biomol Struct Dyn,2020

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