Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity-Reference-Cited by-同舟云学术

Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity

Published:2017-08-08 Issue:20 Volume:36 Page:2951-2967
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Monahan Zachary¹,Ryan Veronica H²,Janke Abigail M³,Burke Kathleen A³,Rhoads Shannon N¹,Zerze Gül H⁴,O'Meally Robert⁵,Dignon Gregory L⁴^ORCID,Conicella Alexander E⁶,Zheng Wenwei⁷,Best Robert B⁷,Cole Robert N⁵,Mittal Jeetain⁴^ORCID,Shewmaker Frank¹^ORCID,Fawzi Nicolas L²³⁶^ORCID

Affiliation:

1. Department of Pharmacology and Molecular Therapeutics Uniformed Services University Bethesda MD USA

2. Neuroscience Graduate Program Brown University Providence RI USA

3. Department of Molecular Pharmacology, Physiology, and Biotechnology Brown University Providence RI USA

4. Department of Chemical and Biomolecular Engineering Lehigh University Bethlehem PA USA

5. Johns Hopkins Mass Spectrometry and Proteomic Facility Johns Hopkins University Baltimore MD USA

6. Graduate Program in Molecular Biology, Cell Biology and Biochemistry Brown University Providence RI USA

7. Laboratory of Chemical Physics National Institutes of Health Bethesda MD USA

Funder

National Science Foundation

National Center for Research Resources

National Institutes of Health

National Institute of General Medical Sciences

National Institute of Mental Health

Basic Energy Sciences

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201696394

Reference84 articles.

1. Protein aggregation diseases: pathogenicity and therapeutic perspectives

2. Phase Separation: Linking Cellular Compartmentalization to Disease

3. Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

4. Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles

5. The quantitative proteome of a human cell line

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