Activation loop phosphorylation regulates B‐Raf in vivo and transformation by B‐Raf mutants-Reference-Cited by-同舟云学术

Activation loop phosphorylation regulates B‐Raf in vivo and transformation by B‐Raf mutants

Published:2015-12-10 Issue:2 Volume:35 Page:143-161
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Köhler Martin¹²³⁴,Röring Michael¹²³⁴,Schorch Björn²³⁴,Heilmann Katharina²⁴,Stickel Natalie³⁴⁵,Fiala Gina J³⁴⁶⁷,Schmitt Lisa C¹²⁴,Braun Sandra¹²⁶,Ehrenfeld Sophia¹⁴,Uhl Franziska M¹⁴,Kaltenbacher Thorsten¹⁴,Weinberg Florian¹²⁴,Herzog Sebastian²⁶⁷,Zeiser Robert⁵⁶⁸⁹,Schamel Wolfgang W⁶⁷¹⁰,Jumaa Hassan⁶⁷¹¹,Brummer Tilman¹²⁴⁶⁸

Affiliation:

1. Faculty of Medicine Institute of Molecular Medicine and Cell Research Albert‐Ludwigs‐University (ALU) Freiburg Germany

2. Centre for Biological Systems Analysis ZBSA ALU Freiburg Germany

3. Spemann Graduate School for Biology and Medicine ALU Freiburg Germany

4. Faculty of Biology ALU Freiburg Germany

5. Department of Hematology and Oncology University Medical Center ALU Freiburg Germany

6. Centre for Biological Signalling Studies BIOSS ALU Freiburg Germany

7. Department of Molecular Immunology Faculty of Biology University of Freiburg Freiburg Germany

8. Comprehensive Cancer Centre Freiburg Germany

9. German Consortium for Translational Cancer Research DKTK Standort Freiburg Germany

10. Center for Chronic Immunodeficiency CCI University Medical Center Freiburg Germany

11. Institute of Immunology University Hospital Ulm Ulm Germany

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201592097

Reference62 articles.

1. SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation

2. The intermediate-activity L597VBRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway

3. Positive Regulation of A-RAF by Phosphorylation of Isoform-specific Hinge Segment and Identification of Novel Phosphorylation Sites

4. Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

5. The Mouse B-raf Gene Encodes Multiple Protein Isoforms with Tissue-specific Expression

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